Phenytoin versus Leviteracetam for Seizure Prophylaxis after brain injury – a meta analysis
نویسندگان
چکیده
منابع مشابه
Phenytoin versus Leviteracetam for Seizure Prophylaxis after brain injury – a meta analysis
BACKGROUND Current standard therapy for seizure prophylaxis in Neuro-surgical patients involves the use of Phenytoin (PHY). However, a new drug Levetiracetam (LEV) is emerging as an alternate treatment choice. We aimed to conduct a meta-analysis to compare these two drugs in patients with brain injury. METHODS An electronic search was performed in using Pubmed, Embase, and CENTRAL. We include...
متن کاملComparison of levetiracetam versus phenytoin for seizure prophylaxis in patients with traumatic brain injury: A meta-analysis
ion sheets. Extracted data included patient’s demographics, study type, intervention, and outcome. We defined seizures as primary outcome. 1184 unduplicated papers identified by our search of which 1106 were excluded by reading the abstract and titles. 72 papers were removed by reading the full text. Finally 6 studies (Cohort studies) were selected for analysis. There is no superiority of eithe...
متن کاملA cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury.
BACKGROUND Recent data indicate comparable efficacy and safety for levetiracetam (LEV) when compared with phenytoin (PHT) for prophylaxis of early seizures after traumatic brain injury. The purpose of this study was to conduct a cost-minimization analysis, from the perspective of both the acute care institution (cost) and patient (charges), comparing these two strategies. METHODS A decision t...
متن کاملCost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury
OBJECTIVE There has been growing interest in newer anti-epileptic drugs (AEDs) for seizure prophylaxis in the intensive care setting because of safety and monitoring issues associated with conventional AEDs like phenytoin. This analysis assessed the cost-effectiveness of levetiracetam versus phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury (TBI). MET...
متن کاملRetrospective analysis of levetiracetam compared to phenytoin for seizure prophylaxis in adults with traumatic brain injury.
BACKGROUND Phenytoin is standard of care for seizure prophylaxis following traumatic brain injury (TBI). Levetiracetam, an alternative antiepileptic drug, is utilized for seizure prophylaxis despite limited data supporting its use. OBJECTIVE Our primary outcome was post-TBI seizure activity measured by electroencephalogram (EEG) for levetiracetam versus phenytoin. Secondary outcomes were leng...
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ژورنال
عنوان ژورنال: BMC Neurology
سال: 2012
ISSN: 1471-2377
DOI: 10.1186/1471-2377-12-30